Category: Статии

Fibrosarcoma in rabbit

Dr Spas Spasov, Unites Veterinary Clinic

Fibrosarcoma in rabbits are malignancy rapidly grow soft tissues tumor. Can affect cats dogs and rabbits . The couse of fibrosarcoma in rabbit also can be a viral infection (polyomavirus, malignant rabbit fibroma virus)

Clinical case

Case description

Rabbit, female , entire , 5 years old was evaluated because of sings of anorexia and apathy .

History

The owners reported that a week ago the rabbit progressively stops eating. The last two days it didn’t eat at all. Тhe rabbit has regularly deworming and vaccination. The rabbit eats hay and rabbit granules only and lives in an apartment and never go outside, there are no others animals in the apartment.

Clinical manifestations Anorexia, cachexia, apathy, unilateral uveitis, normal temperature (38.5). Clinical examination revealed all of the body (back, neck, abdomen and all the legs) nodules, which are not painful, mobile, not tempered and pigmented .The size of the nodules was variable from 1 to 5 centimeters. Some nodules were ulcerated and bleeding, and still painless. Such formations are not observed in the nose and the ears, and the front part of the head.

Diagnostic approach:

We did not find any abnormalities on the X-ray examination of the chest and abdomen. A nodule was surgically removed by cutting.

Symptomatic therapy was appointed until the results of the histopathological examination:
  • Metoclopramide-0,5mg / kg
  • Ranitidine-4 mg / kg
  • Simethicone-65mg / rabbit
  • Meloxicam-1mg / kg
  • Enrofloxacin, 10 mg / kg
  • Intravenous infusion Hartman 4ml / kg / hour.
So designated therapy lasted about 10 days pending the results of pathological examination The condition of the animal slightly improved, which is expressed in phrases in appearance of appetite. The animal took small amounts of food.

Diagnosis:

Fibrosarcoma

The prognosis for this type of tumors is garded to poor. Because of poor condition of the patient and the prognosis owners decided to euthanased the rabbit.


Публикувано за първи път в Vets on the balkans

Green coat, hypothyroidism, lymphoma and carcinoma of the sebaceous glands.

Dr Spas Spasov, Unites Veterinary Clinic

Case presentation:

A twelve year old female, entire Labrador Retriever, presented with skin ulcers over the low lid region of the eyes, feet, face, back and legs. According to the owners the animal has become more lethargic, less active on walks and not as playful in the last twelve months.They attributed this to the age of the animal. At referring vet took a blood sample to do hematology and biochemistry, which did not show abnormalities. They treated the animal with amoxicillin with clavulanic acid.

Diagnostic approach.

  • * microscopic examination- Negative for ectoparasites
  • * impression smear- Colonized neutrophils with cocci bacteria.
  • * microbiology- Staphylococcus aureus pure culture sensitive to amoxicillin with clavulanic acid* Level of TT4 in blood was Low <6 nmol/L>

Treatment:

  • * Local therapy shampoo containing benzoyl peroxide. Name(Peroxyderm)
  • * Systemic antibiotic – amoxicillin with clavulanic acid.
  • * Levothyroxine 0.2mg / kg once daily.

Follow up:

Two weeks after starting treatment, the owners reported that Cleo feels much better and has increased her exercise activity and she is playful. There were fewer skin ulcers predominantly over the front legs and around the eyes but ulcers were superficial. The follow up examination showed a shiny healthy coat, with few skin lesions on the legs.

The only thing that worried the owners was that Cleo’s neck had turned green. Blood was taken to test her TT4 levels and to determine whether we need to change the dose of levothyroxine.

I believe the reason for the green coat is probably heavily chlorinated water and frequent bathing at the beginning of therapy. (This is not proven by research).

The skin ulcers were much larger and bleeding, and her lymph nodes were double the size. Ulcers on her face were approximately 5cm in diameter. An abdominal ultrasound was performed and showed enlarged mesenteric lymph nodes. Fine needle aspirates of the enlarged lymph nodes and punch biopsies of the skin were taken at this time. The result of the FNA revealed- The cell population is homogeneus excibiting several blastic cells, with granular cromatin and inconspicuous cytoplasm. Several mitotic figures are also present. Random, plasma cells are observed accompaniating the neoplastic lymphoblasts. The result of the skin punch biopsy revealed changes characteristic of Sebaceous carcinoma. Based on the new evidence and the results, chemotherapy was recommended but the owners declined. They agreed to a less aggressive therapy with oral prednisolone 2mg/kg , levothyroxine 0.3 mg/kg and gabanevral 10mg/kg and local therapy with prednisolone. Six months later, Cleo’s disease was stable, with significantly smaller lymph nodes and skin lesions.